DEFINITION

bio DEFINITION Osteogenisis imperfecta (OI) is a rargon contractable disorder of collagen deduction associated with wide-cut spectrum of musculoskeletal problems, al almost notably bowing and fractures of the extremities, muscle builder weakness, ligamentous laxity, and spinal deformities. (Binder, 386). Other collagen-containing extraskeletal tissues, much(prenominal) as the sclerae, the teeth, and the heart valves argon also affected to a variable degree. OI has a uncouth feature of bony fragility associated with defective formation of collagen by osteoblasts and fibroblasts.

(Smith, 1983, 13) This disease, involving defective development of the coincidence tissues, is usually the root of the autosomal dominant gene, but commode also be the run of the autosomal recessive gene. intuitive mutations are common and the clinical presentation of the disease system to be quite broad. (Binder, 386) OI is most commonly referred to as unannealed bones, but another(prenominal) call include: fragilitas ossium, hyp...If you want to apprehend a replete(p) essay, order it on our website: Orderessay

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